How to extend lifespan? What does it depend on, and what are its limits?
Life longevity is a reverse of degradation of biological systems, and research of methods to avert it.
Collecting medical tracebacks from hospitals around the world and computing risk of deeper causes to recommend early diagnostics and lifestyle changes
Generalization of Tetris: A strategic game with a variety of morphing shapes flowing through topological holes (like digestive tract) with increasing variety and speed, and complementaries (like matching Tetris bricks) that interact to break down into smaller ones, and a global goal to sustain their flow from clogging the system.
Instead of moving the falling brick, move the entire tetris frame in the rain of tetris parts; make the frame walls semi-permeable sometimes, and emulate life form eating bricks, and medical interventions to alleviate clogging.
I think, the idea of Shapeflow may have great explanatory power and potential for impact, especially, if we devise a game -- let's call it "Body" -- where this structure that you (as ingested substance (say, game player)) is travelling through, is a human body that is getting sick or clogged over time, and your target, as a substance, is to go successfully through that network of metabolic pathways. Kids (or maybe AlphaZeros) playing such games might devise many strategies that we do not know of... and, no cheating, dear AI -- with going through all the necessary parts, where you get extra points -- so, that you wouldn't suddenly convert the gamified human body into a topological doughnut.
// if we devise a game -- let's call it "Body" -- where this structure that you (as ingested substance (say, game player)) is travelling through, is a human body that is getting sick or clogged over time, and your target, as a substance, is to go successfully through that network of metabolic pathways. //
oh, love it! in my MUTANTU book, the readers comically explore the inside of the body, like blood vessels and intestines (where the action of my comics happens!) :)
As much as you may think this is an art, going through a human body as a game world would be highly (I mean it: highly) educational, that could result in kids gaining confidence in actually doing something about human bodies. For example, if the game had special extra tools, like what you collect a big mushroom in Super Mario Bros, giving extra powers to move through certain pathways, unclogging congested arteries, and letting grandmother see the world again without flickering eyesight, or getting a super gun, that allows to cut through, or fix certain pathways... That game could be so fun (and educational!) to play. But I should encourage moving to Shapeflow page with further comments, as this topic is more general it seems. ;)